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Novitsky et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 9
doi: 10.3205/ctt-2010-No9-abstract53
© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "4th Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation",
Saint Petersburg, Russia, September 18–20, 2010

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Immunological monitoring in patients with lymphoproliferative disorders after autologous hematopoietic stem cell transplantation

Andrey V. Novitsky, Vladimir Y. Nikitin, Dmitriy А. Gornostayev, Аndrey М. Ivanov

Medical Military Academy, Saint-Petersburg, Russia

Correspondence: Andrey V. Novitsky, Dept. of Bone marrow transplantation of the Medical Military Academy, Lebedev str 6 A, 194044, Saint-Petersburg, Russia, E-mail: anov1@spam is badmail.ru

Abstract

Background. Hematopoietic stem cell transplantation (HSCT) is the therapy of choice in aggressive and treatment-resistant malignant lymphomas. The immunological reconstitution of lymphoma patients is problematic in the early period after auto-HSCT.

Materials and methods. Immunological monitoring of 4 patients with malignant lymphomas took place. Flow cytometric analysis was performed with a “Cytomics FC500”, before auto-PHSCT and after peripheral blood cell reconstitution.

Results. A complete response was achieved in all patients. After peripheral blood cell reconstitution, a Т-h cell immunodeficiency was detected, characterized by a significant decrease in T helper numbers and activated T-lymphocyte cytotoxic predominance, along with a rise in the common T-lymphocyte percentage, with a dramatic misbalance in the whole T-lymphocyte population. Besides this, a raised HLA-DR-positive T-lymphocyte level was detected. A marked reduction in the B-lymphocyte population and activated B-cells was found, and a number of humoral immunity indices such as serum IgА were also decreased.

Conclusion. In all auto-PHSCT patients, regardless of a disease stage and morphology, we observed the identical immunological disturbances alongside a complete response, indicating a secondary T-h cell mediated immune deficiency, with cytotoxic activated T-lymphocyte predominance in combination with В-cell immunodeficiency.

Keywords: immunological screening, auto-PSCT, immunodeficiency, immunity, lymphoproliferative disorders, lymphomas

 

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