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Kucher et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 9
doi: 10.3205/ctt-2010-No9-abstract13
© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "4th Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation",
Saint Petersburg, Russia, September 18–20, 2010

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Should the levels of macro and micronutrients be routinely tested after hematopoietic stem cell transplantation?

Maxim A. Kucher, Abdulbasir A. Ganapiev, Arnold F. Dolgodvorov, Irina A. Gorbacheva, Boris V. Afanasyev

R.M. Gorbacheva Memorial Institute of Children Hematology and Transplantation, Chair of internal medicine of stomatologic faculty, Pavlov State Medical University, Saint-Petersburg, Russia

Correspondence: Maxim A. Kucher, R.M. Gorbacheva Memorial Institute of Children Hematology and Transplantation, Saint-Petersburg Pavlov State Medical University, 6/8, Tolstoy str., Saint-Petersburg, 197022, Russia, E-mail: doctorkucher@spam is badyandex.ru

Abstract

Introduction: A frequent problem during hematopoietic stem cell transplantation (HSCT) is an imbalanced development of macro and micronutrients, which are essential for reparation, immune functions, and hematopoiesis, because of the impaired intake, raised expense and the losses.

Purpose: To define levels of macro and micronutrients, and to estimate their influence on HSCT effectiveness.

Materials and methods:
We analyzed data from 15 allogeneic SCT recipients, 11 of them underwent allogeneic non-related HSCT, and 4 allogeneic related HSCT. 10 of the patients had acute myeloid leukemia, 2 acute lymphoblastic leukemia, and 3 other hematological malignances. The patients’ median age was 27.1 (15–46) years. All patients with gastrointestinal toxicity received a standard nutrition support regimen. Atomic absorption photospectrometry analysis was used for a dynamic estimation of macro and micronutrients in the plasma and erythrocytes at the beginning of conditioning regimen, and at D+1, D+7, and D+14.

Results: After HSCT 9 patients were in remission on D+100, and 6 patients had died. Independent of the type of treatment and conditioning regimen, all patients exhibited an increased concentration of calcium, sodium was in the normal range, and zinc was lowered. From the revealed tendencies it is necessary to note a considerable decrease in the concentration of copper and zinc on D+14, and magnesium decreased in 50% of patients. In all 6 patients who died, the deficiency of zinc and copper was marked.

Conclusions:
Imbalance of macro and micronutrients is a frequent complication after HSCT. Early diagnostics will allow the correction of their levels in a timely way, leading to an optimization of hematopoiesis and the reparation processes.

Keywords: hematopoietic stem cell transplantation, macronutrients, micronutrients, zinc, copper

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