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Kotova et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 9
doi: 10.3205/ctt-2010-No9-abstract76
© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "4th Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation",
Saint Petersburg, Russia, September 18–20, 2010

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Successful autologous hematopoietic stem cell transplantation as second line treatment for plasma cell leukemia

Natalia A. Kotova1, Anna V. Klimovich1, Vladimir N. Vavilov2, Nina E. Osipova2, Elena G. Egorova1, Irina A. Samorodova1, Vsevolod G. Potapenko1, Elena Y. Darskaya2, Boris V. Afanasyev2, Nadejda V. Medvedeva1

1City Clinical Hospital No 31, Hematology and Oncology Department with Chemotherapy Services for Adult Patients, Saint-Petersburg, Russia; 2R.M. Gorbacheva Memorial Institute of Children Hematology and Transplantation, Pavlov State Medical University, Saint-Petersburg, Russia

Correspondence: Natalia A. Kotova, City Clinical Hospital No 31, Hematology and Oncology Department with Chemotherapy Services for Adult Patients, 3, pr. Dinamo, Saint-Petersburg, 197110, Russia, E-mail: kotova80@spam is badyahoo.ca

Abstract

We report on a case of primary plasma cell leukemia (PCL) in a 55-year-old man who was admitted to our clinic with fatigue, sweating, and pain in the left part of his abdomen. Clinical examination revealed hepatosplenomegaly. Laboratory studies: WBC 17.7х109/L, circulating plasma cells 10.6х109/L, Hb 10.7 g/dl, beta2 MG 6.8 mg/dL, bone marrow aspirate: 31.4% of plasma cell with 3% plasmablasts and 14.6% proplasmacytes among them. No M-component, no hyperproteinemia, osteolytic lesions, or renal failure were observed. He was diagnosed with primary PCL.

The second case concerned a 53-year-old woman who presented with chest pains, a moderate degree of renal failure, fatigue, and multiple osteolytic lesions. A diagnosis of secondary PCL was made. Laboratory studies: WBC 15.4х109/L, circulating plasma cells 2.31х109/L, Hb 6.6 g/dl, beta2 MG 11.2 mg/dL, bone marrow aspirate: 60.0% of plasma cell with 31% plasmablasts and 14.6% proplasmacytes among them. LDH 1018 U/L, an IgG M-component was determined.

Initially both patients were treated with a PAD regimen. In the first case disease progression was after the 2nd cycle and in the second case after the 3rd cycle. They received second-line therapy of two cycles of EDAP-therapy and achieved a very good partial response.

Both patients underwent autologous stem cell infusion after a conditioning regimen with 200 mg/m2 melphalan and are in complete remission 6 months after transplantation.

Keywords: plasma cell leukemia (PCL), autologous stem cell transplantation

 

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