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ctt-journal > Shman et al. (Abstract)

Shman et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 12
doi: 10.3205/ctt-2011-No12-abstract05

© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "5th Raisa Gorbacheva Memorial Meeting Hematopoietic Stem Cell Transplantation in Children and Adults", Saint Petersburg, Russia, September 18–20, 2011

Preliminary Program

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CMV infection and early immune reconstitution after allogeneic hematopoietic stem cell transplantation in children

Tatyana V. Shman, Yuliya E. Mareika, Svetlana O. Sharapova, Nina V. Minakovskaya

Belarusian Research Center for Pediatric Oncology and Hematology, Minsk, Belarus

Correspondence: Tatyana V. Shman, Belarusian Research Center for Pediatric Oncology and Hematology, Pos. Lesnoe-2, 223040, Minsk reg., Belarus, E-mail: t_shman@spam is badyahoo.com

Abstract

The clinical effect of allogeneic hematopoietic stem cell transplantation (HSCT) can be limited by low immunological recovery resulting in infectious complications and relapses. Graft versus host disease and cytomegalovirus (CMV) infection affect the speed of the immune recovery after HSCT.

The aim was to analyze the early immunological reconstitution in children with CMV infection after allogeneic Т-cell replete HSCT.

Methods:
Immune recovery was analyzed in groups of patients without infection (CMV-, n=69), and with CMV infection (CMV+, n=45) activated until day 100. Percentage and absolute counts of B-cells, natural killer cells (NK), T-cells, helper and cytotoxic T-cells, and activated T-cells were evaluated at day +30, +60 and +100 after HSCT.

Results: No difference in immune recovery was found in the CMV- versus the CMV+ group at day +30, because in most cases CMV activation was diagnosed 30 days post HSCT; with a median of day +48. A significant increased percentage of T-cells and cytotoxic T-cells, lower content of NK cells, decreased percentage and absolute content of B-cells in the CMV+ group in comparison with CMV- was revealed at day +60. At day +100 a significant increase in the absolute count of cytotoxic T-cells and T-cells, and a decrease in B-cell percentages in the CMV+ group versus the CMV- one was detected.

In conclusion, increased total T-cell count as well as cytotoxic T-cells, and a delayed recovery of B-cells was detected in patients with CMV infection within the first months after HSCT.

Keywords: allogeneic hematopoietic stem cell transplantation, immune reconstitution, CMV infection