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Lawitschka (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 12
doi: 10.3205/ctt-2011-No12-abstract73

© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "5th Raisa Gorbacheva Memorial Meeting Hematopoietic Stem Cell Transplantation in Children and Adults", Saint Petersburg, Russia, September 18–20, 2011

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Late complications in children and adolescents after allogeneic hematopoietic stem cell transplantation

Anita Lawitschka

St. Anna Children’s Hospital, Vienna, Austria

Correspondence: Dr. Anita Lawitschka, St. Anna Children’s Hospital, Vienna, Austria, Kinderspitalgasse 6, 1090 Vienna, Austria, E–mail: anita.lawitschka@spam is badstanna.at

Abstract

Advances in techniques, supportive care, and increasing indications have resulted in an increasing number of long-term survivors after pediatric HSCT. Late complications represent a heterogeneous group of sequelae, often as a combination of the underlying disease, its primary treatment, the conditioning regimen, and various transplant-associated complications. Immune reconstitution and GvHD play a crucial role in this context. In contrast to adult patients these complications occur in a developing organ system of a growing child with an extended period to deal with late effects and a complex transition from pediatric to adult medicine.

The assurance of multisystem organ function and development, normal endocrine homeostasis and psychosocial development is significant for an overall successful outcome and quality of life. This highlights the importance of appropriate and systematic long-term follow-up with accurate diagnosis and early intervention.

The main aims of this review are to present an overview of pediatric late complications and of possible preventive strategies. Recommendations regarding HSCT-aftercare and the establishment of multidisciplinary health care will also be provided.

Keywords: HSCT, late complications, follow-up