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ctt-journal > Koptev et al. (Abstract)

Koptev et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 12
doi: 10.3205/ctt-2011-No12-abstract20

© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "5th Raisa Gorbacheva Memorial Meeting Hematopoietic Stem Cell Transplantation in Children and Adults", Saint Petersburg, Russia, September 18–20, 2011

Preliminary Program

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Vascular wall remodeling of non-Hodgkin malignant lymphomas

Vladimir D. Koptev, Tatiana I. Pospelova, Natalia V. Skvortsova, Ludmila M. Kopteva

Novosibirsk State University, Novosibirsk State Medical University, Novosibirsk, Russia

Correspondence: Vladimir D. Koptev, Novosibirsk State Medical University, 27b-33, Geroev truda str. Novosibirsk, 6300055, Russia, E-mail: chaton06@spam is badrambler.ru

Abstract

Aim: To estimate character and dynamics of vascular wall remodeling in non-Hodgkin malignant lymphomas before and after treatment.

Methods: The study consisted of 111 patients with non-Hodgkin malignant lymphomas before and after polychemotherapy. Their mean age was 54.4 ± 1.1 years. Ultrasonic research was executed with a "LOGIC 400" (USA), using the gauge of 7.5 MHz. As a reference vessel, a humeral artery was used with measurements of the intima-media complex thickness (IMT), vessel diameter (D) and the modified Kernogan index (IMT/D) by standard techniques.

Results: At the onset of disease, signs of hypertrophic vascular wall remodeling of the humeral artery are revealed: an increase IMT and Kernogan index, and the reduction of internal and constancy of the external diameter. Degree of expressiveness of changes had a direct correlation with the disease stage. After carrying out polychemotherapy and remission achievement at I–II disease stages, the normalization of the investigated parameters was noted, and at III–IV disease stages an authentic improvement could be measured.

Conclusions: Dynamics research of the vascular wall remodeling can serve as one criterium of development of disease and polychemotherapy efficiency.

Keywords: lymphomas, Kernogan index, vascular remodeling