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ctt-journal > Ilyin et al. (Abstract)

Ilyin et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 3, No. 12
doi: 10.3205/ctt-2011-No12-abstract02

© The Authors. This abstract is provided under the following license: Creative Commons Attribution 3.0 Unported

Abstract accepted for "5th Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation",
Saint Petersburg, Russia, September 18–20, 2011

Preliminary Program

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Evolution of methods of Total Body Irradiation

Nikolay V. Ilyin, Julia N. Vinogradova, Aleksander M. Chervyakov

Federal State Institution Russian Research Centre for Radiology and Surgical Technologies (RRCRST) Ministry of the Health and Social Development of the Russian Federation, St. Petersburg, Russia

Correspondence: Nikolay V. Ilyin, Federal State Institution Russian Research Centre for Radiology and Surgical Technologies Ministry of the Health and Social Development of the Russian Federation, Pesochny, Leningradskaya St., 70, 197758, St. Petersburg, Russia, E-mail: ilyin_prof@spam is badmail.ru

Abstract

Total body irradiation (TBI) is one of kinds of systemic radiation therapy that supposes total (systemic) antitumor effects by using ionizing radiation. TBI is distinguished by single and fractionated, by unit and cumulative doses (low, average, and high dose variants); to be used as an independent method of therapy in tumor chemoresistance (low dose variant), or as an element of a conditioning regimen with or without chemotherapy before auto- or allogeneic hematopoietic stem cell transplantation. Independently of the TBI cumulative dose, radiation should be induced to the whole body, including the skin, uniformly and precisely. TBI has several advantages over chemotherapy. As tumor and stem cells are highly sensitive, cross-resistance between radiation and chemotherapy is practically absent. During irradiation, the absorption effect does not develop as it does with chemotherapy, but a direct linear dependence between the effect of TBI and the cumulative dose has been observed. Moreover, TBI affects non-dividing stem cells, independently of the oxygenic effect. Finally, it possesses an important and significant immunosuppressive effect in conditioning. Over the 50-year period that TBI has been in use, there have been many different sources, beam modifications, single and cumulative doses, dose power, and fractionation schemes. The effect of the dose power on hyperfractionation has reduced, as has the frequency of late pulmonary complications in irradiation.

Over the past 25 years RRCRST has been working on perfecting its TBI methods. In 2009 they registered a patent called “Method of the total patient's body irradiation”, where firstly a necessary uniformity of body irradiation is achieved at sufficient dose power, which enables the use of mostly low- and average dose variants of TBI for oncohematological needs, and provides high precision of dose absorption. Low- and average dose variants of TBI will be used as an independent method of therapy and conditioning regimen, as well as before transplantation of stem cells jointly with leading hematological centers.

Keywords: total body irradiation, methods