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Shats et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 2, No. 5, 2009
doi: 10.3205/ctt-2009-No5-abstract59
© The Authors. This abstract is provided under the following license:
Creative Commons Attribution 3.0 Unported


Abstract accepted for "Joint EBMT Pediatric Working Party – 3rd Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation", Saint Petersburg, Russia, September 17–20, 2009

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Aggressiveness of tumor resection improves survival in pediatric malignant gliomas

Ludmila I. Shats1, Margarita B. Belogurova1, Olga G. Zheludkova 2

1City Hospital № 31, St. Petersburg, Russia; 2Clinic Research Center of Hematology, Oncology, and Immunology, Moscow, Russia

Correspondence: City Hospital № 31, pr. Dinamo, 3, St. Petersburg, Russia, Phone/Fax: +7 (812) 235 07 21, E-mail: deton.hospital31@inbox.ru

Abstract

Over a 13-year period (1994–2007) 48 children between 3 and 18 years of age with anaplastic astrocytoma (26 pts) and glioblastoma multiforme (22 pts) were treated with surgery, local radiation therapy, and different regimens of chemotherapy. The retrospective analysis of survival was provided.  In our study there was a statistically significant difference in overall survival (OS) between patients with malignant gliomas who underwent a greater-than-90% resection of the tumor and those who underwent a less-than-90% tumor’s resection (5-year OS 42% vs 20% P=0.013). This difference held up stronger for patients with anaplastic astrocytoma who underwent total and subtotal resection (5-year OS 88.8% vs 43% of P=0.0036). A greater-than-90% surgical resection of newly-diagnosed malignant gliomas in children confers a statistical survival advantage when followed by local field irradiation and any kind of chemotherapy.

Figure 1.


Keywords:
anaplastic astrocytoma, glioblastoma multiforme, pediatric malignant glioma, neurosurgery, children

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