Palutke et al. (Abstract)
Cellular Therapy and Transplantation (CTT), Vol. 2, No. 5, 2009
doi: 10.3205/ctt-2009-No5-abstract74
© The Authors. This abstract is provided under the following license:
Creative Commons Attribution 3.0 Unported
Abstract accepted for "Joint EBMT Pediatric Working Party – 3rd Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation", Saint Petersburg, Russia, September 17–20, 2009
Unusual B-cell lymphoproliferative disorders and the new WHO classification
Margarita Palutke
Wayne State University School of Medicine, Detroit, Michigan USA
Correspondence: Margarita Palutke, MD Professor of Pathology, Wayne State University School of Medicine, Detroit, Michigan USA, E-mail: editors@ctt-journal.com
Abstract
There is a group of chronic B-cell lymphoproliferative disorders that at this time are difficult to classify, many of which are thought to originate in the spleen. The terms B-cell lymphoma with villous lymphocytes, hairy cell leukemia variant, and splenic diffuse red pulp small lymphocytic lymphoma have been used. The WHO puts some of these entities into the splenic B-cell lymphoma/leukemia unclassifiable category.
We have studied a group of such disorders-which have come to us for consultation—with a variety of diagnoses, including: hairy cell leukemia, hairy cell leukemia variant, splenic marginal zone leukemia, prolymphocytic leukemia, and atypical chronic lymphocytic leukemia. In addition to morphological evaluations and flow cytometric immunophenotyping, immunohistochemical and cytogenetic studies were performed in an attempt to achieve a clinically useful diagnosis.
Keywords: chronic lymphoproliferative disorders, splenic lymphomas
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