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ctt-journal > Lyamkina et al. (Abstract)

Lyamkina et al. (Abstract)

Cellular Therapy and Transplantation (CTT), Vol. 2, No. 5, 2009
doi: 10.3205/ctt-2009-No5-abstract16
© The Authors. This abstract is provided under the following license:
Creative Commons Attribution 3.0 Unported

Abstract accepted for "Joint EBMT Pediatric Working Party – 3rd Raisa Gorbacheva Memorial Meeting on Hematopoietic Stem Cell Transplantation", Saint Petersburg, Russia, September 17–20, 2009

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Anemias in lymphomas: pathogenesis mechanisms

Anna S. Lyamkina, Tatiana I. Pospelova

The State Medical University, City Hematological Center, Novosibirsk, Russia

Correspondence: Anna S. Lyamkina, GOU of the highest professional education "Novosibirsk State Medical University of Federal Agency of Healthcare and Social Development", 630091, Novosibirsk, 52, Krasniy Prospect, Russia, Phone/Fax: +7 (383) 279-94-06, E-mail: post_gem@mail.ru


Aims: To spot the value of blood serum cytokines (IL-1β, IL-6, TNF-α, IF-γ) in the development of an anemic syndrome in patients with lymphoproliferative diseases.

Methods: We inspected 88 patients with lymphoproliferative diseases: T and B–cellular non–Hodgkin’s lymphomas and multiple myeloma. The level of serum interleukins (IL-1β, IL-6, TNF-α, IF-γ) was identified.

Results: Patients with lymphoproliferative diseases and an anemia had average levels of IL-1β, TNF-α, IF-γ in their blood serum that were 3.4, 2.8, and 14.4 times higher respectively than in patients with lymphomas without an anemia (p<0.05). The return correlation between levels of IL-1β, TNF-α, IF-γ and the level of erythropoietin serum (r=–0.79) confirms the importance of IL-1β, TNF-α, IF-γ in an anemia pathogenesis at hemoblastoses. For 8.3% of patients with lymphomas and an anemia,  myelodysplasia tags, recorded levels of IL-1β and TNF-α were twice as high as patients with normal erythron. This indicates a probable role of the researched cytokines in the development of secondary myelodysplasia in patients with lymphomas.

The return correlation between IL-6 and erythron of bone marrow was available in patients with multiple myeloma (r=–0.96). IL-6 raises a proliferation of myeloma cells, which—in turn—displace and depress a proliferation of remaining sprouts of myelopoiesis, including erythroid.

Conclusions: The cited data bears the importance of cytokines IL-1β, IL-6, TNF-α, and IF-γ in a pathogenesis of an anemic syndrome for patients with lymphoproliferative diseases.

Keywords: cytokines, lymphoproliferative diseases, anemia, non–Hodgkin’s lymphoma, multiple myeloma

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