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Wright et al. abstract

Please cite this article as follows: Wright GP, King JWL and Stauss HJ. Generation of regulatory T cells by T cell receptor gene transfer. Cell Ther Transplant. 2008;1:e.000020.01. doi:10.3205/ctt-2008-en-000020.01

 

Generation of regulatory T cells by T cell receptor gene transfer

Graham Peter Wright, Judy Wai-Ling King and Hans J Stauss
Abstract

Our lab and others have demonstrated T cell receptor (TCR) gene transfer as an efficient way of redirecting the specificity of a bulk T cell population to that of a known antigen. Thus far there has been considerable effort put into the use of TCR gene transfer into conventional CD8+ and CD4+ T cells in order to initiate or augment immune responses. There has, as yet, been little investigation into the potential use of TCR gene therapy at the other end of the spectrum: control of immune pathology using regulatory T cells. Here we will briefly discuss the evidence indicating that the generation of Ag-specific Tregs, potentially via TCR gene transfer, may be an efficacious treatment for various forms of immune-pathology and briefly outline the challenges towards realizing the full potential of this type of therapy.

Keywords: regulatory T cell, immunotherapy, T cell receptor (TCR) gene transfer

Please cite this article as follows: Wright GP, King JWL and Stauss HJ. Generation of regulatory T cells by T cell receptor gene transfer. Cell Ther Transplant. 2008;1:e.000020.01. doi:10.3205/ctt-2008-en-000020.01

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