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Shipounova et al. abstract (MSC)

Please cite this article as follows: Shipounova (Nifontova) I, Svinareva D, Chertkov J, Drize N. Mesenchymal stem cells: precursor hierarchy. Cell Ther Transplant. 2008;1:e.000022.01. doi:10.3205/ctt-2008-en-000022.01


Mesenchymal stem cells: precursor hierarchy

Irina Shipounova (Nifontova), Daria Svinareva, Josef Chertkov, Nina Drize
Abstract

The hierarchy of stromal precursors is the focus of this research. It has been previously shown that transplantation of the bone marrow plug under the renal capsule of the syngeneic animal leads to the formation of the foci of ectopic hematopoiesis, where a stromal microenvironment is formed by the donor's mesenchymal stem cells (MSC). In the irradiated recipients such foci are 2-3 times larger than in non-irradiated foci due to "inducible" precursors that are more differentiated than MSC. Along with the in vivo tests, the method of in vitro estimation of concentration of clonogenic stromal precursors (CFU-F) is widely used. However, the hierarchical arrangement of the described precursors is still unclear. This study describes the alterations in the number of mentioned precursors in the ectopic hematopoietic foci formed in the irradiated recipients. CFU-F was shown to be the closest MSC progeny thus far, while "inducible" precursor cells–stromal multipotent precursors–are at a lower position in the hierarchy and possibly enlarge the hematopoietic territory in the irradiated recipients directly.

Keywords: mesenchymal stem cells (MSC), colony forming units- fibroblasts (CFU-F), hematopoietic ectopic foci, long-term bone marrow culture, hierarchy of precursor cells

Please cite this article as follows: Shipounova (Nifontova) I, Svinareva D, Chertkov J, Drize N. Mesenchymal stem cells: precursor hierarchy. Cell Ther Transplant. 2008;1:e.000022.01. doi:10.3205/ctt-2008-en-000022.01

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