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Shevchenko et al. abstract

Please cite this article as follows: Shevchenko YL, Novik AA, Kuznetsov AN, Afanasyev BV, Lisukov IA, Rykavicin OA, Myasnikov AA, Melnichenko VY, Fedorenko DA, Ionova TI, Ivanov RA, and Gorodokin G. Autologous hematopoietic stem cell transplantation in multiple sclerosis. Cell Ther Transplant. 2008;1:e.000025.01. doi:10.3205/ctt-2008-en-000025.01

 

Autologous hematopoietic stem cell transplantation in multiple sclerosis

Yury L. Shevchenko, Andrei A. Novik, Alexey N. Kuznetsov, Boris V. Afanasiev, Igor A. Lisukov, Oleg A. Rykavicin, Аlexandr A. Myasnikov, Vladimir Y. Melnichenko, Denis A. Fedorenko, Tatyana I. Ionova, Roman A. Ivanov, and Gary Gorodokin on behalf of the Russian Cooperative Group for Cellular Therapy
Abstract

Background: Although there is no effective cure for this disease, high-dose chemotherapy (HDCT), together with autologous hematopoietic stem cell transplantation (auto-HSCT) offers promising results in the treatment of multiple sclerosis (MS) patients.
Methods: In this paper we present results of a prospective clinical study of safety and efficacy of HDCT+auto-HSCT in MS patients. One hundred and nine patients with various types of MS were included in this study. The patients underwent early, conventional, or salvage/late transplantation.
Results: The transplantation procedure was well tolerated by MS patients, with no transplant-related deaths at all. The efficacy analysis was performed in 79 patients. Forty-two achieved an objective improvement of neurological symptoms (defined as a ≥0.5 point decrease in EDSS score as compared to the baseline and confirmed over 6 months), and 37 patients had disease stabilization (steady EDSS level as compared to the baseline and confirmed over 6 months). Quality of life (QoL) was assessed in 44 patients. Thirty-nine patients exhibited a QoL response 1 year after transplantation.
Conclusions: This study provides ample evidence in support of HDCT+auto-HSCT efficacy in MS patients. The results obtained show that transplantation appears to be effective in patients with various types of MS.

Keywords: auto-HSCT, multiple sclerosis, quality of life, early, conventional and salvage transplantation

Please cite this article as follows: Shevchenko YL, Novik AA, Kuznetsov AN, Afanasyev BV, Lisukov IA, Rykavicin OA, Myasnikov AA, Melnichenko VY, Fedorenko DA, Ionova TI, Ivanov RA, and Gorodokin G. Autologous hematopoietic stem cell transplantation in multiple sclerosis. Cell Ther Transplant. 2008;1:e.000025.01. doi:10.3205/ctt-2008-en-000025.01

 

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