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King et al. abstract


Please cite this article as follows: King JWL, Wright GP and Stauss HJ. Advances in T cell receptor gene transfer for immunotherapy. Cell Ther Transplant. 2008;1:e.000019.01. doi:10.3205/ctt-2008-en-000019.01

 

Advances in T cell receptor gene transfer for immunotherapy

Judy Wai-Ling King, Graham Peter Wright and Hans J Stauss
Abstract

Adoptive T cell transfer has seen clinical success in the treatment of both malignancies and viral infections. However, one of the main limitations of this strategy has been the difficulty in producing sufficient quantities of antigen-specific T cells. In addition, donor lymphocyte infusions are commonly associated with graft-versus-host disease (GvHD), which carries with it significant morbidity and mortality. Retroviral T cell receptor (TCR) gene transfer is an attractive new strategy by which large numbers of autologous, antigen-specific T cells can be generated, since the TCR is the sole determinant of T cell specificity. The introduced TCR specificity can be targeted against viral antigens or poorly immunogenic targets such as tumor associated antigens, and recent clinical trial data has demonstrated the feasibility of this technique in melanoma patients. Furthermore, TCR gene transfer also has the potential to generate antigen-specific regulatory T cells. This review will focus on recent advances in the field of TCR gene transfer and explore the potential clinical applications of this strategy.

Keywords: immunotherapy, T cell receptor (TCR) gene transfer, cancer


Please cite this article as follows: King JWL, Wright GP and Stauss HJ. Advances in T cell receptor gene transfer for immunotherapy. Cell Ther Transplant. 2008;1:e.000019.01. doi:10.3205/ctt-2008-en-000019.01

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