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Tögel et al. abstract

Please cite this article as follows: Tögel F, and Westenfelder Ch. Mechanisms facilitating regenerative therapies with multipotent marrow stromal cells. Cell Ther Transplant. 2008;1:e.2008-05-22-003-en. doi:10.3205/ctt2008-05-22-003-en

Mechanisms facilitating regenerative therapies with multipotent marrow stromal cells

Florian Tögel, Christof Westenfelder
Abstract

Cell therapy has become a promising new treatment approach for a large number of different diseases, and applications are continually being developed. Bone marrow derived stem cells are currently being tested in clinical trials and have been shown to be promising new therapeutic vehicles. Multipotent marrow stromal cells (MSCs) are a bone marrow derived cell type that can be easily cultured and expanded in vitro and have a broad range of potential and actual therapeutic applications. The mechanism of action of MSCs in the therapeutic situation depends on the disease, and involves differentiation, immunomodulation, paracrine, and anti-apoptotic mechanisms. These mechanisms are discussed in detail in this manuscript.

Keywords: cell therapy, bone marrow stem cells, multipotent marrow stromal cells, mechanism of action, differentiation, apoptosis, immunomodulation, treatment, clinical trials

Please cite this article as follows: Tögel F, and Westenfelder Ch. Mechanisms facilitating regenerative therapies with multipotent marrow stromal cells. Cell Ther Transplant. 2008;1:e.2008-05-22-003-en. doi:10.3205/ctt2008-05-22-003-en 

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