[English]  [Pусский]  [中文]  
 
ctt-journal > Ferrara et al. abstract

Ferrara et al. abstract

Please cite this article as follows: Ferrara JLM, and Levine JE. A New Approach to Therapy for Acute GVHD. Cell Ther Transplant. 2008;1:e.2008-05-26-002-en. doi:10.3205/ctt2008-05-26-002-en

A New Approach to Therapy for Acute GVHD

James L.M. Ferrara, M.D. and John E. Levine, M.D.
Abstract

Graft-versus-host disease (GVHD) is a principal cause of morbidity following allogeneic hematopoietic cell transplantation (HCT). Multiple pre-clinical studies have shown that tumor necrosis factor-α (TNFα) is an important effector of experimental GVHD. Patients treated with etanercept and steroids were more likely to achieve complete response than were patients treated with steroids alone. This difference was observed in HCT recipients of both related donors and unrelated donors. Cytokine blockade may become an important element of treatment for GVHD in the future.

Keywords: bone marrow transplantation, graft versus host disease, GVHD, inflammatory cytokines, TNF-alpha, steroids

Please cite this article as follows: Ferrara JLM, and Levine JE. A New Approach to Therapy for Acute GVHD. Cell Ther Transplant. 2008;1:e.2008-05-26-002-en. doi:10.3205/ctt2008-05-26-002-en

Full text
<-- Previous abstract       Contents       Next abstract -->
<-- Предыдущее резюме      Oглавление         Cледующее резюме -->