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Bubnova et al. abstract

Please cite this article as follows: Bubnova LN, Zaitseva GA, Erokhina LV, Berkos AS, Reutova NV, Belyaeva EV, Petrovskaya MN, Ignatova NK, Koudinova EYe, Minina VM. A comparative study of HLA-A and HLA-В antigens and haplotype distribution among donors of hematopoietic stem cells from Russian and German regions. Cell Ther Transplant. 2008;1:e.2008-05-28-001-en. doi:10.3205/ctt2008-05-28-001-en

A Comparative Study Of HLA-A and HLA-В Antigens and Haplotype Distribution Among Donors Of Hematopoietic Stem Cells From Russian And German Regions

Ludmila N. Bubnova, Galina A. Zaitseva, Ludmila V. Erokhina, Andrej S. Berkos, Natalija V. Reutova, Elena V. Belyaeva, Marina N. Petrovskaya, Natalija K. Ignatova, Ella Ye. Koudinova, Vera M. Minina
Summary

Genetic polymorphism in the HLA system is extremely high, thus rendering a search for individuals exhibiting identical genetic characteristics difficult. Meanwhile, successful allografting of unrelated donor hematopoietic stem cells (allo-HSCT) is determined mainly via genetic similarity between the recipient and donor. A Republican Register that unites the databases of HLA-typed donors from the Russian and Kirov Research Institutes of Hematology and Blood Transfusion, and the blood banks of Nyzhni Novgorod, Rostov-on-Don, Samara, and Pervouralsk has been cooperating for several years with the Stefan Morsch Registry in Germany, performing bilateral donor searches for patients with hemoblastosis.
                
The study has shown that the most pronounced differences in prevalence, both for certain antigens and their haplotypes, are observed between the general cohorts of the German and Russian Registers. Donors from St. Petersburg and Nyhzni Novgorod express maximal similarity in their genetic features. The donors from Samara Region are, for some characteristics, more related to German donors, whereas donors from Kirov possess some features that are typical to Northern folk. This data confirms an urgent need for expansion of the Russian Donor Registry, since the probability of finding a donor in the Russian population is sufficiently higher when performing the search in a local Registry.

Keywords: hematopoietic stem cells, allogeneic transplantation, donor registry, HLA antigens, typing, genotype, haplotype, Russian regions, Germany

Please cite this article as follows: Bubnova LN, Zaitseva GA, Erokhina LV, Berkos AS, Reutova NV, Belyaeva EV, Petrovskaya MN, Ignatova NK, Koudinova EYe, Minina VM. A comparative study of HLA-A and HLA-В antigens and haplotype distribution among donors of hematopoietic stem cells from Russian and German regions. Cell Ther Transplant. 2008;1:e.2008-05-28-001-en. doi:10.3205/ctt2008-05-28-001-en 

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