Børset et al. abstract

Please cite this article as follows: Børset M, Standal Th, Waage A, Sundan A. Hepatocyte growth factor (HGF) in the pathogenesis of multiple myeloma. Cell Ther Transplant. 2008;1:e.2008-05-23-001-en. doi:10.3205/ctt2008-05-23-001-en

Hepatocyte growth factor (HGF) in the pathogenesis of multiple myeloma

Magne Børset, Therese Standal, Anders Waage and Anders Sundan

Abstract

HGF is emerging as a cytokine with an important role in the pathophysiology of multiple myeloma. Originally identified and described as a growth factor for hepatocytes, HGF was later found to have mitogenic, motogenic, or morphogenic effects on several cell types through its interaction with the tyrosine kinase receptor c-Met. This cytokine–receptor pair is implicated in the development and promotion of several types of cancer. The expression of both HGF and c-Met by myeloma cells is one of the traits distinguishing these cells from healthy plasma cells, and seems to be an early step in tumor development. HGF and c-Met have an effect on proliferation, migration, and adhesion of myeloma cells; and research suggests that myeloma cell-produced HGF is an important factor in angiogenesis and bone destruction seen in the majority of patients with multiple myeloma.

Keywords: multiple myeloma, hepatocyte growth factor, HGF, c-Met, hematological cancer, DKK1, RANK, RANKL, OPG, carcinogenesis, bone resorption, bone formation, review

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